Abstract Mucin 1 (MUC1) is a heterodimeric protein formed by two subunits that is aberrantly
overexpressed in human breast cancer and other cancers. Historically, much of the early …

Mucins are the main structural components of mucus that create a selective protective
barrier for epithelial surface and also execute wide range of other physiological functions …

Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective
targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant …

Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and among the
leading causes of cancer-related death worldwide. It is a highly heterogeneous disease …

Prostate cancer is the most common non-cutaneous cancer and the second leading cause
of cancer-associated deaths among men in the United States. Androgen deprivation therapy …

An important clinical challenge in prostate cancer therapy is the inevitable transition from
androgen-sensitive to castration-resistant and metastatic prostate cancer. Albeit the …

The epithelial–mesenchymal transition (EMT) is activated in cancer cells by ZEB1, a
member of the zinc finger/homeodomain family of transcriptional repressors. The mucin 1 …

Castration resistant prostate cancer (CRPC) is responsive to androgen receptor (AR) axis
targeted agents; however, patients invariably relapse with resistant disease that often …

The most common ovarian cancer is epithelial ovarian cancer (EOC) characterised by few
early symptoms, widespread peritoneal dissemination and ascites at advanced stages that …

Aldehyde dehydrogenase 1A1 (ALDH1A1) activity is used as a marker of breast cancer stem
cells; however, little is known about the regulation of ALDH1A1 expression. Mucin 1 (MUC1) …