Revolutionizing medicinal chemistry: the application of artificial intelligence (AI) in early drug discovery

R Han, H Yoon, G Kim, H Lee, Y Lee - Pharmaceuticals, 2023 - mdpi.com
Artificial intelligence (AI) has permeated various sectors, including the pharmaceutical
industry and research, where it has been utilized to efficiently identify new chemical entities …

Amber‐codon suppression for spatial localization and in vivo photoaffinity capture of the interactome of the Pseudomonas aeruginosa rare lipoprotein A lytic …

LF Avila‐Cobian, H Hoshino, ME Horsman… - Protein …, 2023 - Wiley Online Library
The 11 lytic transglycosylases of Pseudomonas aeruginosa have overlapping activities in
the turnover of the cell‐wall peptidoglycan. Rare lipoprotein A (RlpA) is distinct among the …

The essential domain of FtsN triggers cell division by promoting interaction between FtsL and FtsI

KT Park, DJ Park, S Pichoff, S Du, J Lutkenhaus - bioRxiv, 2023 - biorxiv.org
Cell division in bacteria requires the activation of FtsWI at the division site to synthesize
septal peptidoglycan. In E. coli FtsN activates FtsWI and a previous model posited that the …

[PDF][PDF] Return to a Warmer Climate of the Middle Pliocene will Boost Bacterial, Viral and Protozoan Parasite Pathogen Induced Diseases

K Roe - Journal ISSN, 2024 - jelsciences.com
A return to the climate of the middle Pliocene is probable within this century and the
increased temperatures, particularly at higher latitudes, will boost the spread of several …