Helicobacter pylori is an organism associated with ulcer disease and gastric cancer. The
latter is one of the most prevalent malignancies and currently the fourth major cause of …

The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

The thioredoxin (Trx) system, which is composed of NADPH, thioredoxin reductase (TrxR),
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …

Whole-genome sequencing has opened the way for investigating the dynamics and
genomic evolution of bacterial pathogens during the colonization and infection of humans …

Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's
population. Infection with H. pylori causes chronic inflammation and significantly increases …

Diverse mechanisms for pH sensing and cytoplasmic pH homeostasis enable most bacteria
to tolerate or grow at external pH values that are outside the cytoplasmic pH range they must …

Helicobacter pylori is the dominant species of the human gastric microbiome, and
colonization causes a persistent inflammatory response. H. pylori-induced gastritis is the …

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …

The newest version of MUMmer easily handles comparisons of large eukaryotic genomes at
varying evolutionary distances, as demonstrated by applications to multiple genomes. Two …

Gram-negative bacteria characteristically are surrounded by an additional membrane layer,
the outer membrane. Although outer membrane components often play important roles in …