Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Among all existing radionuclides, only a few are of interest for therapeutic applications and
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225 …

With a short particle range and high linear energy transfer, α-emitting radionuclides
demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides …

Use of radiometals in nuclear oncology is a rapidly growing field and encompasses a broad
spectrum of radiotracers for imaging via PET (positron emission tomography) or SPECT …

Simple Summary Currently, there is no treatment that can cure patients with late stage
metastatic prostate cancer. Prostate-specific membrane antigen is a type of protein …

The effectiveness of targeted α-therapy (TAT) can be explained by the properties of α-
particles. Alpha particles are helium nuclei and are~ 8,000 times larger than β−-particles …

Cyclams are 14-membered tetraamine macrocycles which bind strongly to a wide range of
metal ions. Medical interest has centred on clinical trials of a bicyclam for the treatment of …

Purpose The aims of this study were to develop a prostate-specific membrane antigen
(PSMA) ligand for labelling with different radioisotopes of lead and to obtain an …

Over the last decade, targeted alpha therapy has demonstrated its high effectiveness in
treating various oncological diseases. Lead-212, with a convenient half-life of 10.64 h, and …

Targeted alpha-particle therapy (TAT) aims to selectively deliver radionuclides emitting α-
particles (cytotoxic payload) to tumors by chelation to monoclonal antibodies, peptides or …