The mechanism by which vaccine adjuvants enhance immune responses has historically
been considered to be the creation of an antigen depot. From here, the antigen is slowly …

In acute myeloid leukemia (AML), molecular heterogeneity across patients constitutes a
major challenge for prognosis and therapy. AML with NPM1 mutation is a distinct genetic …

B cells exhibit a range of functional responses following TLR engagement including
immunoglobulin and cytokine production, proliferation, antigen presentation and migration …

Tafazzin (TAZ) is a mitochondrial transacylase that remodels the mitochondrial cardiolipin
into its mature form. Through a CRISPR screen, we identified TAZ as necessary for the …

IL-4 plays an essential role in the activation of mature B cells, but less is known about the
role of IL-4 in B cell maturation and tolerance checkpoints. In this study, we analyzed the …

B cells fulfill multifaceted functions that influence immune responses during health and
disease. In autoimmune diseases, such as inflammatory bowel disease, multiple sclerosis …

Background Cystic fibrosis (CF) is an inherited disorder caused by mutations in the CF
transmembrane conductance regulator (CFTR) gene that promotes persistent lung infection …

The purpose of this study was to analyze the expression of miR-146a in PBMCs obtained
from patients with myasthenia gravis (MG) and healthy controls and to investigate the effect …

Micro RNA s have been shown to be important regulators of immune homeostasis as
patients with aberrant micro RNA expression appeared to be more susceptible to …

High titer of anti‐β2‐glycoprotein I antibodies (anti‐β2GPI Ab) plays a pathogenic role in
antiphospholipid syndrome (APS). Numerous studies have focused on the pathological …