This review presents evidence for two overlapping yet distinctive clinical types of sickle cell
disease. The basis of one is the vaso-occlusive crisis; the other is the consequence of …

Sickle cell disease (SCD) is a common monogenetic disorder with high associated morbidity
and mortality. The pulmonary complications of SCD are of particular importance, as acute …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Secondary pulmonary hypertension (PH) is emerging as one of the leading causes of
mortality and morbidity in patients with hemolytic anemias such as sickle cell disease (SCD) …

Sickle cell disease (SCD) is a complex, clinically heterogeneous disorder affecting
approximately 100,000 individuals in the United States and millions worldwide. The disease …

Acute chest syndrome is a frequent cause of acute lung disease in children with sickle-cell
disease. Asthma is common in children with sickle-cell disease and is associated with …

In recent years, evidence has accumulated indicating that the enzyme arginase, which
converts L‐arginine into L‐ornithine and urea, plays a key role in the pathogenesis of …

Asthma is a common comorbidity in sickle cell disease (SCD) with a reported prevalence of
30–70%. The high frequency of asthma in this population cannot be attributed to genetic …

Objectives To prospectively assess longitudinal lung function in children with sickle cell
disease (SCD). Working hypothesis Lung function in SCD children deteriorates with …

Objective To identify factors associated with asthma associated with increased sickle cell
anemia (SCA). Study design Children with SCA (N= 187; mean age 9.6 years, 48% male) …