A1/A2 astrocytes in central nervous system injuries and diseases: Angels or devils?

YY Fan, J Huo - Neurochemistry International, 2021 - Elsevier
Astrocytes play a pivotal role in maintaining the central nervous system (CNS) homeostasis
and function. In response to CNS injuries and diseases, reactive astrocytes are triggered. By …

The multiple faces of the oxytocin and vasopressin systems in the brain

V Grinevich, M Ludwig - Journal of neuroendocrinology, 2021 - Wiley Online Library
Classically, hypothalamic neuroendocrine cells that synthesise oxytocin and vasopressin
were categorised in two major cell types: the magnocellular and parvocellular neurones. It …

Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons

Y Tang, D Benusiglio, A Lefevre, L Hilfiger… - Nature …, 2020 - nature.com
Oxytocin (OT) is a great facilitator of social life but, although its effects on socially relevant
brain regions have been extensively studied, OT neuron activity during actual social …

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

J Wahis, A Baudon, F Althammer, D Kerspern… - Nature …, 2021 - nature.com
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural
circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby …

Captopril alleviates epilepsy and cognitive impairment by attenuation of C3-mediated inflammation and synaptic phagocytosis

X Dong, J Fan, D Lin, X Wang, H Kuang, L Gong… - Journal of …, 2022 - Springer
Evidence from experimental and clinical studies implicates immuno-inflammatory responses
as playing an important role in epilepsy-induced brain injury. Captopril, an angiotensin …

Cognitive impairment in myocardial infarction and heart failure

K Jinawong, N Apaijai, N Chattipakorn… - Acta …, 2021 - Wiley Online Library
Myocardial infarction (MI) occurs when coronary blood flow is decreased due to an
obstruction/occlusion of the vessels, leading to myocardial death and progression to heart …

Assaying microglia functions in vitro

E Maguire, N Connor-Robson, B Shaw, R O'Donoghue… - Cells, 2022 - mdpi.com
Microglia, the main immune modulators of the central nervous system, have key roles in both
the developing and adult brain. These functions include shaping healthy neuronal networks …

[HTML][HTML] High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling

T Gruber, F Lechner, C Murat, RE Contreras… - Cell Reports, 2023 - cell.com
Oxytocin-expressing paraventricular hypothalamic neurons (PVN OT neurons) integrate
afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy …

Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge

RK Roy, F Althammer, AJ Seymour, W Du… - Cell reports, 2021 - cell.com
Neurovascular coupling (NVC), the process that links neuronal activity to cerebral blood flow
changes, has been mainly studied in superficial brain areas, namely the neocortex. Whether …

[HTML][HTML] The Role of Glial Cells in Synaptic Dysfunction: Insights into Alzheimer's Disease Mechanisms

Y Yu, R Chen, K Mao, M Deng, Z Li - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impacts a
substantial number of individuals globally. Despite its widespread prevalence, there is …