Systemic sclerosis is the rheumatic disease with the highest individual mortality. The severity
of the disease is determined by the extent of fibrotic changes to cutaneous and internal …

ABSTRACT Introduction: Systemic sclerosis (SSc), also known as scleroderma, is a complex
orphan disease characterized by early inflammatory features, vascular hyper-reactivity, and …

Background We recently reported histone methyltransferase enhancer of zeste homolog 2
(EZH2) as a key epigenetic regulator that contributes to the dysfunction of innate immune …

Lung fibrosis is a devastating disease characterized by fibroblast accumulation and
extracellular matrix deposition in lungs. However, its molecular and cellular pathogenesis is …

Pulmonary fibrosis is a chronic progressive disease with high incidence, prevalence, and
mortality rates worldwide. It is characterized by excessive accumulation of extracellular …

Previously, the authors reported that neuropilin-1 (NRP1) was significantly increased and
acted as a vital promoter in the metastasis of non-small cell lung cancer (NSCLC). However …

Radiation-induced pulmonary fibrosis (RIPF) is a common consequence of radiation for
thoracic tumors, and is accompanied by gradual and irreversible organ failure. This severely …

Secretory immunoglobulin A (SIgA) is one of the most abundant immunoglobulin subtypes
among mucosa, which plays an indispensable role in the first-line protection against …

Purpose Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of
extracellular matrix (ECM) protein in the lungs. Transforming growth factor (TGF) β-induced …

Purpose: Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive form of NSCLC.
Rarity and poor characterization have limited the development of PSC-tailored treatment …