Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …

Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition
to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce …

Mediators of the initiation, development, and recurrence of periodontitis include the oral
microbiome embedded in subgingival plaque and the host immune response to a dysbiosis …

The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19,
and avian flu is often caused by the uncontrolled innate immune response and destructive …

Interferons (IFN) are crucial for the innate immune response. Slightly more than two decades
ago, a new type of IFN was discovered: the lambda IFN (type III IFN). Like other IFN, the type …

The skin is an active immune organ that functions as the first and largest site of defense to
the outside environment. Serving as the primary interface between host and pathogen, the …

Type III interferons (lambda IFNs) are a quite new, small family of three closely related
cytokines with interferon-like activity. Attention to IFN-λ is mainly focused on direct antiviral …

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease
caused by a novel bunyavirus (SFTS virus, SFTSV). At present there is still no specific …

Estradiol (E2) and progesterone (P) have potent effects on immune function in the human
uterine endometrium which is essential for creating an environment conducive for successful …

Alpha herpesviruses (α-HV) infect host mucosal epithelial cells prior to establishing a life-
long latent infection in the peripheral nervous system. The initial spread of viral particles …