Overview on chikungunya virus infection: from epidemiology to state-of-the-art experimental models

LEC Constant, BF Rajsfus, PH Carneiro… - Frontiers in …, 2021 - frontiersin.org
Chikungunya virus (CHIKV) is currently one of the most relevant arboviruses to public
health. It is a member of the Togaviridae family and alphavirus genus and causes an …

[HTML][HTML] Computational prediction of MoRFs, short disorder-to-order transitioning protein binding regions

A Katuwawala, Z Peng, J Yang, L Kurgan - Computational and Structural …, 2019 - Elsevier
Molecular recognition features (MoRFs) are short protein-binding regions that undergo
disorder-to-order transitions (induced folding) upon binding protein partners. These regions …

Investigating into the molecular interactions of flavonoids targeting NS2B-NS3 protease from ZIKA virus through in-silico approaches

R Yadav, C Selvaraj, M Aarthy, P Kumar… - Journal of …, 2021 - Taylor & Francis
Zika virus (ZIKV), belongs to the flavivirus genus and Flaviviridae family that associated with
serious diseased conditions like microcephaly and other neurological disorders (Guillan …

Spread of a novel Indian Ocean Lineage carrying E1-K211e/E2-V264A of chikungunya virus east/central/South African genotype across the Indian subcontinent …

J Phadungsombat, HA Imad, EE Nakayama… - Microorganisms, 2022 - mdpi.com
The Indian Ocean Lineage (IOL) of the chikungunya virus (CHIKV) East/Central/South
African (ECSA) genotype, which originated in Kenya, spread to the Indian ocean and the …

Folding and structural polymorphism of p53 C-terminal domain: One peptide with many conformations

A Kumar, P Kumar, S Kumari, VN Uversky… - Archives of biochemistry …, 2020 - Elsevier
Abstracts Proteins of the p53 family are best known for their role in the regulation of cell
cycle. The p53 protein, as a model system, has been extensively explored in numerous …

Understanding the penetrance of intrinsic protein disorder in rotavirus proteome

D Kumar, A Singh, P Kumar, VN Uversky… - International journal of …, 2020 - Elsevier
Rotavirus is a major cause of severe acute gastroenteritis in the infants and young children.
The past decade has evidenced the role of intrinsically disordered proteins/regions …

[PDF][PDF] Chikungunya vaccines: An update in 2023

P Roongaraya… - Asian Pacific Journal of …, 2023 - apjai-journal.org
A recent chikungunya outbreak affected 1.5 million cases in more than 60 countries. The
virus causes low mortality but moderate to severe morbidities such as high fever, myalgia …

Chikungunya virus drug discovery: still a long way to go?

MJ Pérez-Pérez, L Delang, LFP Ng… - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: Chikungunya virus (CHIKV) is the etiological agent of a (re) emerging arbovirus
infection, chikungunya fever (CHIKF), that represents a serious health problem worldwide for …

Unstructured biology of proteins from ubiquitin-proteasome system: roles in cancer and neurodegenerative diseases

K Gadhave, P Kumar, SK Kapuganti, VN Uversky… - Biomolecules, 2020 - mdpi.com
The 26S proteasome is a large (~ 2.5 MDa) protein complex consisting of at least 33
different subunits and many other components, which form the ubiquitin proteasomal system …

Japanese encephalitis virus–exploring the dark proteome and disorder–function paradigm

T Bhardwaj, KU Saumya, P Kumar, N Sharma… - The FEBS …, 2020 - Wiley Online Library
Japanese encephalitis virus (JEV) is one of the major causes of viral encephalitis all around
the globe. Approximately 3 billion people in endemic areas are at risk of Japanese …