Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an
endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly …

The discovery of nuclear receptors and transporters has contributed to the development of
new drugs for the treatment of cholestatic liver diseases. Particular progress has been made …

Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly
associated with immune-mediated disorders. In this study, we implemented multitrait joint …

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

Genetic susceptibility to autoimmune liver diseases is conferred mainly by polymorphisms of
genes encoding for the human leukocyte antigens (HLA). The strongest predisposition to …

Primary biliary cholangitis (PBC) is a chronic, progressive cholestatic liver disease in which
the small intrahepatic bile ducts are destroyed by autoimmune reactions. Among …

Primary biliary cholangitis (PBC) is an immune-mediated disease of the hepatobiliary
system that leads to the destruction of small bile ducts, resulting in chronic intrahepatic …

Background The gut-liver axis indicates a close relationship between the gastrointestinal
microbiome (GM) and primary biliary cholangitis (PBC). However, the causality of this …

Primary biliary cholangitis (PBC) is an autoimmune liver disease with striking female
predisposition, and selective destruction of intrahepatic small bile ducts leading to non …

Primary biliary cholangitis (PBC) is a rare autoimmune disease of the liver affecting the small
bile ducts. From a genetic point of view, PBC is a complex trait and several genetic and …