During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

Thymidylate synthase is a target of 5-fluoruracil, a pyrimidine analog used to treat
gastrointestinal and other cancers. The 5-fluorouracil metabolite, fluoro-deoxyuridine …

The published data about thymidylate synthase (TS) expression and its predictive value in
advanced colorectal cancer (CRC) patients receiving fluoropyrimidine‐based chemotherapy …

The cellular transcription factor E2F1 has been identified as a tumor suppressor regulating
the activities of p53 and its homologue TAp73, and promoting apoptosis by the activation of …

Purpose: Patients presenting with locally advanced rectal cancer currently receive
preoperative radiotherapy with or without chemotherapy. Although pathologic complete …

Purpose: There are no reliable prognostic markers that identify gastric cancer patients who
may benefit from adjuvant chemoradiation therapy. E2F-1 was shown to be associated with …

E2F-1 is an intriguing transcription factor that accumulates the integrated signal of the G1-S
transition regulators. Its role in cell fate, as depicted from in vivo models and a few studies on …

Thymidylate synthase (TS) is the enzyme that catalyses the last step in de novo thymidylate
synthesis. It is of interest clinically because it is an effective target for drugs such as 5 …

Thymidylate synthase (TYMS) is an important chemotherapeutic target in non-small cell lung
cancer (NSCLC). Arsenic trioxide (ATO) has been shown to suppress TYMS in a colonic …

The predictive value of thymidylate synthase (TS) expression alone for 5FU-based treatment
of colorectal cancer (CRC) has not been clinically confirmed. Little is known on the …