Tracing the peopling of the world through genomics

R Nielsen, JM Akey, M Jakobsson, JK Pritchard… - Nature, 2017 - nature.com
Advances in the sequencing and the analysis of the genomes of both modern and ancient
peoples have facilitated a number of breakthroughs in our understanding of human …

African genetic diversity and adaptation inform a precision medicine agenda

L Pereira, L Mutesa, P Tindana, M Ramsay - Nature Reviews Genetics, 2021 - nature.com
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …

[HTML][HTML] Population genomics of post-glacial western Eurasia

ME Allentoft, M Sikora, A Refoyo-Martínez… - Nature, 2024 - nature.com
Western Eurasia witnessed several large-scale human migrations during the Holocene,,,–.
Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced …

[图书][B] Who we are and how we got here: Ancient DNA and the new science of the human past

D Reich - 2018 - books.google.com
The past few years have witnessed a revolution in our ability to obtain DNA from ancient
humans. This important new data has added to our knowledge from archaeology and …

Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation

S Fan, JP Spence, Y Feng, MEB Hansen, J Terhorst… - Cell, 2023 - cell.com
We conduct high coverage (> 30×) whole-genome sequencing of 180 individuals from 12
indigenous African populations. We identify millions of unreported variants, many predicted …

The Simons genome diversity project: 300 genomes from 142 diverse populations

S Mallick, H Li, M Lipson, I Mathieson, M Gymrek… - Nature, 2016 - nature.com
Here we report the Simons Genome Diversity Project data set: high quality genomes from
300 individuals from 142 diverse populations. These genomes include at least 5.8 million …

Southern African ancient genomes estimate modern human divergence to 350,000 to 260,000 years ago

CM Schlebusch, H Malmström, T Günther, P Sjödin… - Science, 2017 - science.org
Southern Africa is consistently placed as a potential region for the evolution of Homo
sapiens. We present genome sequences, up to 13x coverage, from seven ancient …

[HTML][HTML] Reconstructing prehistoric African population structure

P Skoglund, JC Thompson, ME Prendergast, A Mittnik… - Cell, 2017 - cell.com
We assembled genome-wide data from 16 prehistoric Africans. We show that the anciently
divergent lineage that comprises the primary ancestry of the southern African San had a …

Loci associated with skin pigmentation identified in African populations

NG Crawford, DE Kelly, MEB Hansen, MH Beltrame… - Science, 2017 - science.org
INTRODUCTION Variation in pigmentation among human populations may reflect local
adaptation to regional light environments, because dark skin is more photoprotective …

Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated

E Elhaik - Scientific Reports, 2022 - nature.com
Abstract Principal Component Analysis (PCA) is a multivariate analysis that reduces the
complexity of datasets while preserving data covariance. The outcome can be visualized on …