Rhodanine as a privileged scaffold in drug discovery

T Tomasic, LP Masic - Current Medicinal Chemistry, 2009 - ingentaconnect.com
Rhodanines, thiazolidine-2, 4-diones and pseudothiohydantoins have become a very
interesting class of heterocyclic compounds since the introduction of various glitazones and …

Tau protein and tau aggregation inhibitors

B Bulic, M Pickhardt, EM Mandelkow, E Mandelkow - Neuropharmacology, 2010 - Elsevier
Alzheimer disease is characterized by pathological aggregation of two proteins, tau and Aβ-
amyloid, both of which are considered to be toxic to neurons. In this review we summarize …

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

JB Baell, GA Holloway - Journal of medicinal chemistry, 2010 - ACS Publications
This report describes a number of substructural features which can help to identify
compounds that appear as frequent hitters (promiscuous compounds) in many biochemical …

Progress and developments in tau aggregation inhibitors for Alzheimer disease

B Bulic, M Pickhardt, E Mandelkow - Journal of medicinal …, 2013 - ACS Publications
Pharmacological approaches directed toward Alzheimer disease are diversifying in parallel
with a growing number of promising targets. Investigations on the microtubule-associated …

Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation

DD Subhedar, MH Shaikh, BB Shingate… - European Journal of …, 2017 - Elsevier
A series of rhodanine incorporated quinoline derivatives were efficiently synthesized using
reusable DBU acetate as ionic liquid and evaluated for their in vitro antitubercular activity …

Synthesis and biological evaluation of new rhodanine analogues bearing 2-chloroquinoline and benzo [h] quinoline scaffolds as anticancer agents

V Ramesh, BA Rao, P Sharma, B Swarna… - European Journal of …, 2014 - Elsevier
Abstract Several rhodanine derivatives (9–39) were synthesized for evaluation of their
potential as anticancer agents. Villsmeier cyclization to synthesize aza-aromatic aldehydes …

Investigation of inhibition effect of rhodanine-N-acetic acid on mild steel corrosion in HCl solution

AO Yüce, R Solmaz, G Kardaş - Materials Chemistry and Physics, 2012 - Elsevier
Corrosion inhibition effect of rhodanine-N-acetic acid (R-NA) on mild steel (MS) corrosion in
0.1 M HCl solution was investigated. For this purpose, potentiodynamic polarization …

Targeting bacterial toxins

ME Ivarsson, JC Leroux… - Angewandte Chemie …, 2012 - Wiley Online Library
Protein toxins constitute the main virulence factors of several species of bacteria and have
proven to be attractive targets for drug development. Lead candidates that target bacterial …

5-(1H-Indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl)alkancarboxylic Acids as Antimicrobial Agents: Synthesis, Biological Evaluation, and Molecular Docking …

V Horishny, V Kartsev, A Geronikaki, V Matiychuk… - Molecules, 2020 - mdpi.com
Background: Infectious diseases symbolize a global consequential strain on public health
security and impact on the socio-economic stability all over the world. The increasing …

Design, synthesis and structure-activity studies of rhodanine derivatives as HIV-1 integrase inhibitors

K Ramkumar, VN Yarovenko, AS Nikitina, IV Zavarzin… - Molecules, 2010 - mdpi.com
Raltegravir was the first HIV-1 integrase inhibitor that gained FDA approval for use in the
treatment of HIV-1 infection. Because of the emergence of IN inhibitor-resistant viral strains …