The locus coeruleus (LC), or 'blue spot', is a small nucleus located deep in the brainstem
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This …

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus
nerve stimulation (tVNS) across basic, translational and clinical research …

Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction,
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and …

The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates
many fundamental brain functions. Studies in humans have suggested that strong LC …

To understand what makes sleep vulnerable in disease, it is useful to look at how wake-
promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity is inhibited …

The locus coeruleus (LC) is a seemingly singular and compact neuromodulatory nucleus
that is a prominent component of disparate theories of brain function due to its broad …

Noradrenaline (NA) release from the locus coeruleus (LC) changes activity and connectivity
in neuronal networks across the brain, modulating multiple behavioral states. NA release is …

For decades, numerous seminal studies have built our understanding of the locus coeruleus
(LC), the vertebrate brain's principal noradrenergic system. Containing a numerically small …

Fluctuations in brain and behavioral state are supported by broadly projecting
neuromodulatory systems. In this study, we use mesoscale two-photon calcium imaging to …

Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …