The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

The potential of human induced pluripotent stem cells (iPSCs) to self-renew indefinitely and
to differentiate virtually into any cell type in unlimited quantities makes them attractive for in …

One week after fertilization, human embryos implant into the uterus. This event requires the
embryo to form a blastocyst consisting of a sphere encircling a cavity lodging the embryo …

After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …

Human naive pluripotent cells can differentiate into extraembryonic trophectoderm and
hypoblast. Here we describe a human embryo model (blastoid) generated by self …

Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Current understandings of cell specification in early mammalian pre-implantation
development are based mainly on mouse studies. The first lineage differentiation event …

Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-
coding RNA (sncRNA) discovery, the currently widely used complementary DNA library …

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …