Cancer is the second leading cause of death globally and is projected to overtake infectious
disease as the leading cause of mortality in Africa within the next two decades. Cancer is a …

Background: Over 100 people die daily from opioid overdose and $78.5 B per year is spent
on treatment efforts, however, the real societal cost is multifold greater. Alternative strategies …

Abstract The African Pharmacogenomics Consortium (APC) was formally launched on the
6th September 2018. This white paper outlines its vision, and objectives towards addressing …

Cytochrome P450 3A4 (CYP3A4) enzyme activity is known to show considerable ethnic
heterogeneity and inter-individual differences, affecting the outcome of drug treatment …

Background Tacrolimus is an approved first-line immunosuppressive agent for kidney
transplantations. Part of interindividual and interethnic differences in the response of …

A One Health lens is increasingly significant to address the intertwined challenges in
planetary health concerned with the health of humans, nonhuman animals, plants, and …

Prostate cancer (PCa) is the second most commonly diagnosed in men worldwide and one
of the most frequent cancers in men in Africa. The heterogeneity of this cancer fosters the …

Drug metabolizing enzymes play a crucial role in the pharmacokinetics and
pharmacodynamics of therapeutic drugs, influencing their efficacy and safety. This review …

Abstract Cytochrome P450 3A4 (CYP3A4) enzyme is involved in the metabolism of about
30% of clinically used drugs, including the antimalarials artemether and lumefantrine …

Cytochrome P450 (CYP450), sulfotransferase (SULT), and glucuronidase (UGT) enzymes
play roles in the phase I and phase II metabolism of most clinically prescribed drugs. As …