Strategies for targeting senescent cells in human disease

NS Gasek, GA Kuchel, JL Kirkland, M Xu - Nature aging, 2021 - nature.com
Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …

[HTML][HTML] Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype

R Kumari, P Jat - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Virus-induced senescence is a driver and therapeutic target in COVID-19

S Lee, Y Yu, J Trimpert, F Benthani, M Mairhofer… - Nature, 2021 - nature.com
Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

R Di Micco, V Krizhanovsky, D Baker… - … reviews Molecular cell …, 2021 - nature.com
Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Senescence and the SASP: many therapeutic avenues

J Birch, J Gil - Genes & development, 2020 - genesdev.cshlp.org
Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …

Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs

Y Li, X Chen, R Jin, L Chen, M Dang, H Cao… - Science …, 2021 - science.org
Current therapeutic strategies such as angiogenic therapy and anti-inflammatory therapy for
treating myocardial infarction have limited success. An effective approach may benefit from …

Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow

X Liu, Y Gu, S Kumar, S Amin, Q Guo, J Wang, CL Fang… - Cell metabolism, 2023 - cell.com
The chronic use of glucocorticoids decreases bone mass and quality and increases bone-
marrow adiposity, but the underlying mechanisms remain unclear. Here, we show that bone …

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

A Lagnado, J Leslie, MH Ruchaud‐Sparagano… - The EMBO …, 2021 - embopress.org
Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro‐
inflammatory phenotype, thought to contribute to aging and age‐related diseases …

Guidelines for minimal information on cellular senescence experimentation in vivo

M Ogrodnik, JC Acosta, PD Adams, FA di Fagagna… - Cell, 2024 - cell.com
Cellular senescence is a cell fate triggered in response to stress and is characterized by
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …

Acute liver failure is regulated by MYC-and microbiome-dependent programs

AA Kolodziejczyk, S Federici, N Zmora, G Mohapatra… - Nature medicine, 2020 - nature.com
Acute liver failure (ALF) is a fulminant complication of multiple etiologies, characterized by
rapid hepatic destruction, multi-organ failure and mortality. ALF treatment is mainly limited to …