The heat shock transcription factors (HSFs) were discovered over 30 years ago as direct
transcriptional activators of genes regulated by thermal stress, encoding heat shock …

Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Abstract Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive
signaling. In addition to playing critical roles in cellular heat shock response, emerging …

Various stress factors leading to protein damage induce the activation of an evolutionarily
conserved cell protective mechanism, the heat shock response (HSR), to maintain protein …

In addition to the deregulation of gene transcriptions and post-translational protein
modifications, the aberrant translation from mRNAs to proteins plays an important role in the …

Pro-inflammatory stress is inherent in any cells that are subject to damage or threat of
damage. It is defined by a number of universal components, including oxidative stress …

There are increasing concerns that the current rate of climate change might outpace the
ability of reef-building corals to adapt to future conditions. Work on model systems has …

Acute myeloid leukemia (AML) is maintained by self-renewing leukemic stem cells (LSCs). A
fundamental problem in treating AML is that conventional therapy fails to eliminate LSCs …

This analytical review summarizes literature data and our own research on HSP70-
dependent mechanisms of neuroprotection and discusses potential pharmacological agents …