Cancer still represents a “nightmare” worldwide, causing annually millions of victims.
Several antiproliferative molecules are currently used as drugs market and offer a …

Resistance to chemotherapy and molecularly targeted therapies is a major problem facing
current cancer research. The mechanisms of resistance to'classical'cytotoxic …

Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …

Despite the great progress in medical sciences, cancer is still a major health problem. Since
the majority of cancer treatment protocols include first-generation chemotherapeutic agents …

Highly dynamic mitotic-spindle microtubules are among the most successful targets for
anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids …

Microtubules are highly dynamic structures, which consist of α-and β-tubulin heterodimers,
and are involved in cell movement, intracellular trafficking, and mitosis. In the context of …

Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …

Since its approval by the FDA in 1992 for the treatment of ovarian cancer, the use of Taxol
has dramatically increased. Although treatment with Taxol has led to improvement in the …

The taxanes, paclitaxel and docetaxel are microtubule-stabilizing agents that function
primarily by interfering with spindle microtubule dynamics causing cell cycle arrest and …

The intracellular location of a protein is crucial to its normal functioning in a cell. Cancer cells
utilize the normal processes of nuclear-cytoplasmic transport through the nuclear pore …