Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …

Abstract I (RPM) presented “The Year In G Protein-Coupled Receptor Research” at ENDO
2009. I first described the diversity of ligands and the five families into which the …

Dehydroepiandrosterone (DHEA) sulfotransferase, known as SULT2A1, converts the
androgen precursor DHEA to its inactive sulfate ester, DHEAS, thereby preventing the …

Adrenal insufficiency (AI) is a potentially life-threatening condition that can be difficult to
diagnose, especially if it is not considered as a potential cause of a child's clinical …

Coincidentally, the release of this Research Topic in Frontiers in Endocrinology takes place
25 years after the discovery of the adrenocorticotropic hormone receptor (ACTHR) by …

Melanocortin-2 receptor accessory protein (MRAP) has an unusual dual topology and
influences the expression, localisation, signalling and internalisation of the melanocortin …

The melanocortin receptors (MCRs) are a family of G protein-coupled receptors that are
activated by melanocortin ligands derived from the proprotein, proopiomelanocortin …

The melanocortin system is composed by the agonists adrenocorticotropic hormone and α, β
and γ-melanocyte-stimulating hormone, and two naturally occurring antagonists, agouti and …

The evolution of the melanocortin receptors (MCRs) is linked to the evolution of
adrenocorticotrophic hormone (ACTH), the melanocyte-stimulating hormones (MSHs), and …