The formation of microbial biofilms enables single planktonic cells to assume a multicellular
mode of growth. During dispersion, the final step of the biofilm life cycle, single cells egress …

Pathogenic microorganisms and their chronic pathogenicity are significant concerns in
biomedical research. Biofilm-linked persistent infections are not easy to treat due to resident …

Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Candida albicans is a common fungus of the human microbiota. While generally a harmless
commensal in healthy individuals, several factors can lead to its overgrowth and cause a …

Highlights•Biofilm formation is a major contributor to pathogenesis during Candida
infection.•C. albicans biofilm formation is a multi-step, highly regulated process.•Cells in …

Antimicrobial resistance is directly responsible for more deaths per year than either
HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at …

Worldwide, the number of infections caused by biofilm-forming fungal pathogens is very
high. In human medicine, there is an increasing proportion of immunocompromised patients …

Biofilms are extremely difficult to eradicate due to their decreased antibiotic susceptibility.
Inducing biofilm dispersion could be a potential strategy to help combat biofilm-related …

Fluconazole has characteristics that make it widely used in the clinical treatment of C.
albicans infections. However, fluconazole has only a fungistatic activity in C. albicans …

The opportunistic fungal pathogen Candida albicans is capable of adhering to the oral
mucosa despite forces created by salivary flow. Although many fungal adhesion proteins …