Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

Z Chen, A Bozec, A Ramming, G Schett - Nature Reviews …, 2019 - nature.com
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of
spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and …

Targeting the PI3K/Akt signaling pathway in pancreatic β‐cells to enhance their survival and function: an emerging therapeutic strategy for type 1 diabetes

I Camaya, S Donnelly, B O'Brien - Journal of Diabetes, 2022 - Wiley Online Library
Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of the
insulin‐producing β‐cells within the pancreas. Islet transplantation represents one cure; …

Fasciola hepatica-Derived Molecules as Regulators of the Host Immune Response

S Ryan, J Shiels, CC Taggart, JP Dalton… - Frontiers in …, 2020 - frontiersin.org
Helminths (worms) are one of the most successful organisms in nature given their ability to
infect millions of humans and animals worldwide. Their success can be attributed to their …

The dual role of antimicrobial peptides in autoimmunity

W Liang, J Diana - Frontiers in immunology, 2020 - frontiersin.org
Autoimmune diseases (AiDs) are characterized by the destruction of host tissues by the host
immune system. The etiology of AiDs is complex, with the implication of multiple genetic …

Gut microbiota-stimulated innate lymphoid cells support β-defensin 14 expression in pancreatic endocrine cells, preventing autoimmune diabetes

M Miani, J Le Naour, E Waeckel-Enée, S chand Verma… - Cell metabolism, 2018 - cell.com
The gut microbiota is essential for the normal function of the gut immune system, and
microbiota alterations are associated with autoimmune disorders. However, how the gut …

Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis

PF Wang, F Jiang, QM Zeng, WF Yin, YZ Hu… - Journal of …, 2024 - Springer
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of
inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been …

Extracellular Vesicles Derived From Trichinella spiralis Muscle Larvae Ameliorate TNBS-Induced Colitis in Mice

Y Yang, L Liu, X Liu, YY Zhang, H Shi, W Jia… - Frontiers in …, 2020 - frontiersin.org
Helminths are masters at modulating the host immune response through a wide variety of
versatile mechanisms. These complex strategies facilitate parasite survival in the host and …

How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and β-cell crosstalk

I Camaya, B O'Brien, S Donnelly - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetes is the fastest growing chronic disease globally, with prevalence increasing at a
faster rate than heart disease and cancer. While the disease presents clinically as chronic …

Parasite-derived proteins for the treatment of allergies and autoimmune diseases

Z Wu, L Wang, Y Tang, X Sun - Frontiers in microbiology, 2017 - frontiersin.org
The morbidity associated with atopic diseases and immune dysregulation disorders such as
asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and …

Effects of helminths and anthelmintic treatment on cardiometabolic diseases and risk factors: A systematic review

K Pham, A Mertelsmann, K Mages… - PLOS Neglected …, 2023 - journals.plos.org
Background Globally, helminth infections and cardiometabolic diseases often overlap in
populations and individuals. Neither the causal relationship between helminth infections …