Mitochondrial electron transport chain, ROS generation and uncoupling

RZ Zhao, S Jiang, L Zhang… - … journal of molecular …, 2019 - spandidos-publications.com
The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as
well as the electron transporters ubiquinone and cytochrome c. There are two electron …

The significance of mitochondrial dysfunction in cancer

Y Luo, J Ma, W Lu - International journal of molecular sciences, 2020 - mdpi.com
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …

Modulating ROS to overcome multidrug resistance in cancer

Q Cui, JQ Wang, YG Assaraf, L Ren, P Gupta… - Drug Resistance …, 2018 - Elsevier
The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Mitochondrial uncoupling: a key controller of biological processes in physiology and diseases

S Demine, P Renard, T Arnould - Cells, 2019 - mdpi.com
Mitochondrial uncoupling can be defined as a dissociation between mitochondrial
membrane potential generation and its use for mitochondria-dependent ATP synthesis …

Mitochondrial disorders of the OXPHOS system

E Fernandez‐Vizarra, M Zeviani - FEBS letters, 2021 - Wiley Online Library
Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …

Raman spectroscopy in cell biology and microbiology

G Pezzotti - Journal of Raman Spectroscopy, 2021 - Wiley Online Library
The Raman spectrum of living cells and microorganisms contains highly specific fingerprint‐
like signatures, useful in unequivocally identifying different species and interpreting …

Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment

M Golpich, E Amini, Z Mohamed… - CNS neuroscience & …, 2017 - Wiley Online Library
Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

Mitochondrial structure and bioenergetics in normal and disease conditions

M Protasoni, M Zeviani - International journal of molecular sciences, 2021 - mdpi.com
Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

From OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies

CA Schmidt, KH Fisher-Wellman, PD Neufer - Journal of Biological …, 2021 - ASBMB
Biological energy transduction underlies all physiological phenomena in cells. The
metabolic systems that support energy transduction have been of great interest due to their …

Hypoxic pulmonary vasoconstriction: from molecular mechanisms to medicine

KJ Dunham-Snary, D Wu, EA Sykes, A Thakrar… - Chest, 2017 - Elsevier
Hypoxic pulmonary vasoconstriction (HPV) is a homeostatic mechanism that is intrinsic to
the pulmonary vasculature. Intrapulmonary arteries constrict in response to alveolar hypoxia …