Saponins regulate intestinal inflammation in colon cancer and IBD

J Dong, W Liang, T Wang, J Sui, J Wang, Z Deng… - Pharmacological …, 2019 - Elsevier
The saponins are natural surface-active glycosides which are the principal components of
many popular herbal medicinal plants such as ginseng, astragalus, and bupleurum. Recent …

Astragalus membranaceus as a Drug Candidate for Inflammatory Bowel Disease: The Preclinical Evidence

M Hou, Y Leng, Y Shi, Z Tan, X Min - The American Journal of …, 2023 - World Scientific
Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that include
Crohn's disease (CD) and ulcerative colitis (UC). Today, IBD has no successful treatment. As …

Astragaloside Ⅳ alleviates ulcerative colitis by regulating the balance of Th17/Treg cells

Y Zhong, W Liu, Y Xiong, Y Li, Q Wan, W Zhou, H Zhao… - Phytomedicine, 2022 - Elsevier
Background Restoring immune homeostasis by targeting the Th17/Treg response is a
potentially valuable therapeutic strategy for ulcerative colitis (UC). Astragaloside IV (AS-Ⅳ) …

[HTML][HTML] Echinacoside alleviated LPS-induced cell apoptosis and inflammation in rat intestine epithelial cells by inhibiting the mTOR/STAT3 pathway

L Li, G Wan, B Han, Z Zhang - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Inflammatory bowel disease (IBD) is a chronic and progressive inflammatory condition of
colon and small intestine. Echinacoside (ECH) is a phenylethanoid glycoside that …

[HTML][HTML] MicroRNA-216b targets HK2 to potentiate autophagy and apoptosis of breast cancer cells via the mTOR signaling pathway

T Liu, P Ye, Y Ye, B Han - International Journal of Biological …, 2021 - ncbi.nlm.nih.gov
Patients suffering from breast cancer (BC) still have a poor response to treatments, even
though early detection and improved therapy have contributed to a reduced mortality …

Astragaloside II ameliorated podocyte injury and mitochondrial dysfunction in streptozotocin-induced diabetic rats

J Su, C Gao, L Xie, Y Fan, Y Shen, Q Huang… - Frontiers in …, 2021 - frontiersin.org
Astragaloside II (AS II), a novel saponin purified from Astragalus membranes, has been
reported to modulate the immune response, repair tissue injury, and prevent inflammatory …

Astragalus polysaccharide alleviates ulcerative colitis by regulating the balance of Tfh/Treg cells

Y Zhong, Q Xiao, Z Kang, J Huang, W Ge… - International …, 2022 - Elsevier
The immunomodulatory function of natural active ingredients has long been a focus of
scientific research, with recent hotspots reporting targeted modulation of the follicular helper …

Astragaloside IV alleviates intestinal barrier dysfunction via the AKT-GSK3β-β-catenin pathway in peritoneal dialysis

J He, M Wang, L Yang, H Xin, F Bian, G Jiang… - Frontiers in …, 2022 - frontiersin.org
Background and aims: Long-term peritoneal dialysis (PD) causes intestinal dysfunction,
including constipation, diarrhea, or enteric peritonitis. However, the etiology and …

Targeting mammalian target of rapamycin: prospects for the treatment of inflammatory bowel diseases

NA Lashgari, NM Roudsari, S Momtaz… - Current Medicinal …, 2021 - ingentaconnect.com
Inflammatory bowel disease (IBD) is a general term for a group of chronic and progressive
disorders. Several cellular and biomolecular pathways are implicated in the pathogenesis of …

Astragaloside III enhances anti-tumor response of NK cells by elevating NKG2D and IFN-γ

X Chen, X Chen, J Gao, H Yang, Y Duan… - Frontiers in …, 2019 - frontiersin.org
Natural killer (NK) cells play an irreplaceable role in the development of colon cancer, in
which antitumor function of NK cells was impaired. Astragaloside III is a natural compound …