Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a
central role in maintaining basic cellular functions such as growth, survival, and metabolism …

Proteins encoding phosphotyrosine binding (PTB) domains function as adaptors or scaffolds
to organize the signaling complexes involved in wide-ranging physiological processes …

Objective—ADP-induced P2y12 signaling is crucial for formation and stabilization of an
arterial thrombus. We demonstrated recently in platelets from healthy subjects that insulin …

The present invention relates to a first group of novel genes, here identified as “genomic
address messenger” or “GAM” genes, and a second group of novel operon-like genes, here …

ContextGiven the numerous, yet inconsistent, reports of genetic variants being associated
with acute coronary syndromes (ACS), there is a need for comprehensive validation of ACS …

The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …

IRS proteins are cellular adaptor molecules that mediate many of the key metabolic actions
of insulin. When tyrosine is phosphorylated by the activated insulin receptor, IRS proteins …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

Modular pleckstrin homology (PH) and phospho-tyrosine binding (PTB) domains are present
in a remarkably large number of proteins from yeast to humans. With a common core fold …

Background—The common insulin resistance syndrome, with obesity, dyslipidemia,
hyperglycemia, and hypertension, is associated with increased risk of atherosclerosis. Early …