Severe covid-19 pneumonia has posed critical challenges for the research and medical
communities. Older age, male sex, and comorbidities increase the risk for severe disease …

Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the
European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Background Invasive mechanical ventilation in critically ill adults involves adjusting the
fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation …

Background The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting …

Rationale: Mortality in acute respiratory distress syndrome (ARDS) has decreased after the
adoption of lung-protective strategies. Lower Vt, lower driving pressure (ΔP), lower …

Acute respiratory distress syndrome (ARDS) is a complex syndrome of acute lung injury
leading to noncardiogenic pulmonary edema from many causes that is heterogenous in its …

Background: This document provides evidence-based clinical practice guidelines on the use
of mechanical ventilation in adult patients with acute respiratory distress syndrome (ARDS) …

Fifteen recommendations and a therapeutic algorithm regarding the management of acute
respiratory distress syndrome (ARDS) at the early phase in adults are proposed. The Grade …