Functional importance of the D614G mutation in the SARS-CoV-2 spike protein
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus
which binds its cellular receptor angiotensin-converting enzyme 2 (ACE2) and enters hosts …
which binds its cellular receptor angiotensin-converting enzyme 2 (ACE2) and enters hosts …
[HTML][HTML] SARS-CoV-2 new variants: Characteristic features and impact on the efficacy of different vaccines
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its
new variants reported in different countries have posed a serious threat to human health and …
new variants reported in different countries have posed a serious threat to human health and …
Tomatidine and patchouli alcohol as inhibitors of SARS-CoV-2 enzymes (3CLpro, PLpro and NSP15) by molecular docking and molecular dynamics simulations
Considering the current dramatic and fatal situation due to the high spreading of SARS-CoV-
2 infection, there is an urgent unmet medical need to identify novel and effective approaches …
2 infection, there is an urgent unmet medical need to identify novel and effective approaches …
Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants
The SARS-CoV-2 Spike protein needs to be in an open-state conformation to interact with
ACE2 to initiate viral entry. We utilise coarse-grained normal mode analysis to model the …
ACE2 to initiate viral entry. We utilise coarse-grained normal mode analysis to model the …
Accelerating COVID-19 research using molecular dynamics simulation
The COVID-19 pandemic has emerged as a global medico-socio-economic disaster. Given
the lack of effective therapeutics against SARS-CoV-2, scientists are racing to disseminate …
the lack of effective therapeutics against SARS-CoV-2, scientists are racing to disseminate …
Free SARS-CoV-2 spike protein S1 particles may play a role in the pathogenesis of COVID-19 infection
AV Letarov, VV Babenko, EE Kulikov - Biochemistry (Moscow), 2021 - Springer
The imbalance of the renin-angiotensin system is currently considered as a potentially
important factor of the pathogenesis of COVID-19 disease. It has been shown previously in …
important factor of the pathogenesis of COVID-19 disease. It has been shown previously in …
SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains
COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The
infection and death rates associated with this pandemic are strikingly variable in different …
infection and death rates associated with this pandemic are strikingly variable in different …
GlycoGrip: Cell Surface-Inspired Universal Sensor for Betacoronaviruses
Inspired by the role of cell-surface glycoproteins as coreceptors for pathogens, we report the
development of GlycoGrip: a glycopolymer-based lateral flow assay for detecting SARS-CoV …
development of GlycoGrip: a glycopolymer-based lateral flow assay for detecting SARS-CoV …
[HTML][HTML] Structural modelling of SARS-CoV-2 alpha variant (B. 1.1. 7) suggests enhanced furin binding and infectivity
Abstract The B. 1.1. 7 SARS-CoV-2 strain that has emerged in the UK in early December
presents seven mutations and three deletions on S-protein structure that could lead to a …
presents seven mutations and three deletions on S-protein structure that could lead to a …
D614G substitution of SARS-CoV-2 spike protein increases syncytium formation and virus titer via enhanced furin-mediated spike cleavage
YW Cheng, TL Chao, CL Li, SH Wang, HC Kao… - MBio, 2021 - Am Soc Microbiol
Since the D614G substitution in the spike (S) protein of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) emerged, the variant strain has undergone a rapid expansion …
coronavirus 2 (SARS-CoV-2) emerged, the variant strain has undergone a rapid expansion …