Detection and analysis of chiral molecules as disease biomarkers
The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …
N6-methyladenosine links RNA metabolism to cancer progression
Abstract N6-methyladenosine (m6A) is the most abundant mRNA modification. With the
development of antibody-based sequencing technologies and the findings of m6A-related …
development of antibody-based sequencing technologies and the findings of m6A-related …
The roles of 2-hydroxyglutarate
X Du, H Hu - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
2-Hydroxyglutarate (2-HG) is structurally similar to α-ketoglutarate (α-KG), which is an
intermediate product of the tricarboxylic acid (TCA) cycle; it can be generated by reducing …
intermediate product of the tricarboxylic acid (TCA) cycle; it can be generated by reducing …
IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives
Genes encoding for isocitrate dehydrogenases 1 and 2, IDH1 and IDH2, are frequently
mutated in multiple types of human cancer. Mutations targeting IDH1 and IDH2 result in …
mutated in multiple types of human cancer. Mutations targeting IDH1 and IDH2 result in …
Metabolism, activity, and targeting of D-and L-2-hydroxyglutarates
Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human
cancer, resulting in neomorphic enzymes that convert α-ketoglutarate (α-KG) to 2 …
cancer, resulting in neomorphic enzymes that convert α-ketoglutarate (α-KG) to 2 …
Oncometabolites in renal cancer
C Yong, GD Stewart, C Frezza - Nature Reviews Nephrology, 2020 - nature.com
The study of cancer metabolism has evolved vastly beyond the remit of tumour proliferation
and survival with the identification of the role of 'oncometabolites' in tumorigenesis. Simply …
and survival with the identification of the role of 'oncometabolites' in tumorigenesis. Simply …
Hypoxia-mediated increases in L-2-hydroxyglutarate coordinate the metabolic response to reductive stress
Metabolic adaptation to hypoxia is critical for survival in metazoan species for which reason
they have developed cellular mechanisms for mitigating its adverse consequences. Here …
they have developed cellular mechanisms for mitigating its adverse consequences. Here …
Applications of NMR spectroscopy to systems biochemistry
TWM Fan, AN Lane - Progress in nuclear magnetic resonance spectroscopy, 2016 - Elsevier
The past decades of advancements in NMR have made it a very powerful tool for metabolic
research. Despite its limitations in sensitivity relative to mass spectrometric techniques, NMR …
research. Despite its limitations in sensitivity relative to mass spectrometric techniques, NMR …
Molecular pathways: isocitrate dehydrogenase mutations in cancer
O Clark, K Yen, IK Mellinghoff - Clinical Cancer Research, 2016 - AACR
IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to α-
ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP+. Mutations in …
ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP+. Mutations in …
Systems proteomics of liver mitochondria function
INTRODUCTION Over the past two decades, continuous improvements in “omics”
technologies have driven an ever-greater capacity to define the relationships between …
technologies have driven an ever-greater capacity to define the relationships between …