Hypothermia is a widely used clinical practice for neuroprotection and is a well-established
method to mitigate the adverse effects of some clinical conditions such as reperfusion injury …

Importance Epilepsy affects at least 1.2% of the population, with one-third of cases
considered to be drug-resistant epilepsy (DRE). For these cases, focal cooling therapy may …

Abstract Study Objectives The substantia nigra pars reticulata (SNR) is a major output
nucleus of the basal ganglia. Animal studies have shown that lesions of the SNR cause …

Objective. Local cooling of the brain as a therapeutic intervention is a promising alternative
for patients with epilepsy who do not respond to medication. In vitro and in vivo studies have …

Hypothermia is widely used in the medical field to protect organs or tissues from damage.
Different research fields have different explanations of the protection mechanism of …

This study aimed to understand the mechanism by which brain cooling terminates epileptic
discharge. Cortical slices were prepared from rat brains (n= 19) and samples from patients …

Although the focal brain cooling technique is widely used to examine brain function, the
effects of cortical temperature at various levels on sensory information processing and …

BACKGROUND Functional mapping in awake craniotomy has the potential risk of electrical
stimulation-related seizure. The authors have developed a novel mapping technique using a …

Epilepsy is a relatively common condition, but more than 30% of patients have refractory
epilepsy that is inadequately controlled by or is resistant to multiple drug treatments. Thus …

A focal brain cooling system for treatment of refractory epilepsy that is implantable and
wearable may permit patients with this condition to lead normal daily lives. We have …