Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

Over a long period of time, humans have explored many natural resources looking for
remedies of various ailments. Traditional medicines have played an intrinsic role in human …

Microbial natural products have provided an important source of therapeutic leads and
motivated research and innovation in diverse scientific disciplines. In recent years, it has …

Natural products (NPs) are considered as a cornerstone for the generation of bioactive leads
in drug discovery programs. However, one of the major limitations of NP drug discovery …

In natural product research, microbial metabolites have tremendous potential to provide new
therapeutic agents since extremely diverse chemical structures can be found in the nearly …

Streptomyces have the potential to produce more than 30 secondary metabolites; however,
the expression of most metabolite biosynthetic gene clusters is cryptic or silent. Indeed, the …

Covering: 2010 up to 2017 Life on Earth is characterized by a remarkable abundance of
symbiotic and highly refined relationships among life forms. Defined as any kind of close …

Co-culture of different microbes simulating the natural state of microbial community may
produce potentially new compounds because of nutrition or space competition. To mine its …

Actinomycetes are a rich source of bioactive natural products important for novel drug leads.
Recent genome mining approaches have revealed an enormous number of secondary …

Microbial culture conditions in the laboratory, which conventionally involve the cultivation of
one strain in one culture vessel, are vastly different from natural microbial environments …