The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …

The striatum plays a central role in motor control and motor learning. Appropriate responses
to environmental stimuli, including pursuit of reward or avoidance of aversive experience all …

Deficits in decoding rewarding (and aversive) signals are present in several
neuropsychiatric conditions such as depression and addiction, emphasising the importance …

The cortex projects to the dorsal striatum topographically, to regulate behaviour,–, but
spiking activity in the two structures has previously been reported to have markedly different …

The ventral tegmental area (VTA) and nucleus accumbens (NAc) are essential for learning
about environmental stimuli associated with motivationally relevant outcomes. The task of …

Cholinergic neurons are widespread, and pharmacological modulation of acetylcholine
receptors affects numerous brain processes, but such modulation entails side effects due to …

Striatal cholinergic interneurons (ChIs) are central for the processing and reinforcement of
reward‐related behaviors that are negatively affected in states of altered dopamine …

The purpose of this review is to bridge the gap between earlier literature on striatal
cholinergic interneurons and mechanisms of microcircuit interaction demonstrated with the …

It is widely accepted that dorsal striatum neurons participate in either the direct pathway
(expressing dopamine D1 receptors) or the indirect pathway (expressing D2 receptors) …

Background Environmental reward–predictive stimuli provide a major source of motivation
for adaptive reward pursuit behavior. This cue-motivated behavior is known to be mediated …