The strategies involved in the development of therapeutics for neurodegenerative disorders
are very complex and challenging due to the existence of the blood-brain barrier (BBB), a …

In recent years, extracellular vesicles (EVs) have emerged as promising biomarkers, cell-
free therapeutic agents, and drug delivery carriers. Despite their great clinical potential, poor …

Neurodegenerative diseases constitute a group of pathologies whose etiology remains
unknown in many cases, and there are no treatments that stop the progression of such …

Alzheimer's disease (AD) is a progressive degenerative neurological illness with insidious
onset. Due to the complexity of the pathogenesis of AD and different pathological changes …

Exosomes are potent mediators of physiological and pathological processes. In Alzheimer's
disease and inflammatory disorders, due to exosomes' distinctive ability to cross the blood …

A lack of stratification methods in patients with amyotrophic lateral sclerosis (ALS) is likely
implicated in therapeutic failures. Regional diversities and pathophysiological abnormalities …

As major public health concerns associated with a rapidly growing aging population,
neurodegenerative diseases (NDDs) and neurological diseases are important causes of …

Alzheimer's disease (AD) is a kind of dementia that creates serious challenges for sufferers'
memory, thinking, and behavior. It commonly targeting the aging population and decay the …

Over the past two decades, increased research has highlighted the connection between
endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an …

Abstract Background Modified Jianpi Yangzheng decoction (mJPYZ), as an empirical
decoction of Traditional Chinese medicine has been shown significantly to prolong the …