Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …

Neuroblastomas harbor ALK aberrations clinically resistant to crizotinib yet sensitive pre-
clinically to the third-generation ALK inhibitor lorlatinib. We conducted a first-in-child study …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

Risk-based treatment approaches for neuroblastoma have been ongoing for decades.
However, the criteria used to define risk in various institutional and cooperative groups were …

Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course
ranges from spontaneous tumor regression to fatal progression. To investigate the molecular …

Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system.
Roughly half of these tumours regress spontaneously or are cured by limited therapy. By …

The majority of patients with neuroblastoma have tumors that initially respond to
chemotherapy, but a large proportion will experience therapy-resistant relapses. The …

Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …

Neuroblastoma is the most common extra-cranial solid tumor of childhood and the most
common in the first year of life. It is a unique malignancy in that infants often present with …