Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

The lateral hypothalamic area (LHA) coordinates an array of fundamental behaviors,
including sleeping, waking, feeding, stress and motivated behavior. The wide spectrum of …

The overconsumption of highly caloric and palatable foods has caused a surge in obesity
rates in the past half century, thereby posing a healthcare challenge due to the array of …

Ghrelin, an acylated peptide hormone of 28 amino acids, is an endogenous ligand of the
released growth hormone secretagogue receptor (GHSR). Ghrelin has been isolated from …

Type 1 estrogen receptor-expressing neurons in the ventrolateral subdivision of the
ventromedial hypothalamus (VMHvlEsr1) play a causal role in the control of social …

In recent years, the relationship between intestinal microbiota (IM) and the pathogenesis of
type 2 diabetes mellitus (T2DM) has attracted much attention. The beneficial effects of IM on …

Oestrogen receptor alpha (ERα) signalling in the ventromedial hypothalamus (VMH)
contributes to energy homeostasis by modulating physical activity and thermogenesis …

Homeostasis of bone metabolism is regulated by the central nervous system, and mood
disorders such as anxiety are associated with bone metabolism abnormalities, yet our …

Dysfunctions in growth hormone (GH) secretion increase the prevalence of anxiety and
other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been …