The role of silicon in drug discovery: a review

JL Panayides, DL Riley, F Hasenmaile… - RSC Medicinal …, 2024 - pubs.rsc.org
This review aims to highlight the role of silicon in drug discovery. Silicon and carbon are
often regarded as being similar with silicon located directly beneath carbon in the same …

Exploring the multitarget potential of iridoids: advances and applications

P Grover, L Mehta, A Malhotra, G Kapoor… - Current Topics in …, 2023 - ingentaconnect.com
Iridoids are secondary plant metabolites that are multitarget compounds active against
various diseases. Iridoids are structurally classified into iridoid glycosides and non …

Verbascoside inhibits progression of glioblastoma cells by promoting Let‐7g‐5p and down‐regulating HMGA2 via Wnt/beta‐catenin signalling blockade

WQ Jia, JW Zhu, CY Yang, J Ma, TY Pu… - Journal of Cellular …, 2020 - Wiley Online Library
Glioblastoma (GBM) continues to show a poor prognosis despite advances in diagnostic
and therapeutic approaches. The discovery of reliable prognostic indicators may …

Naphthoquinones inhibit formation and viability of Yersinia enterocolitica biofilm

NI Di Marco, PL Páez, CSM Lucero-Estrada… - World Journal of …, 2021 - Springer
The capacity of different naphthoquinones to inhibit and eradicate Yersinia enterocolitica
biofilm was investigated and possible mechanisms of action were evaluated. Inhibition of …

Inhibition of DNA synthesis in the transcription system of Taq DNA polymerase by various iron and cobalt (II) tris-dioximate clathrochelates: In vitro study and X-ray …

OA Varzatskii, AV Vologzhanina, VV Novikov… - Inorganica Chimica …, 2018 - Elsevier
A series of the iron and cobalt (II) mono-and bis-clathrochelates was in vitro tested in the
transcription system of Taq DNA polymerase (DNAP), based on polymerase chain reaction …

Aporphinoid alkaloids inhibit biofilm formation of Yersinia enterocolitica isolated from sausages

NI Di Marco, CR Pungitore… - Journal of Applied …, 2020 - academic.oup.com
Aims of the study The ability of Yersinia enterocolitica strains to form biofilms and the
capacity of different alkaloids to inhibit biofilm formation were investigated. Methods and …

[HTML][HTML] Phytochemistry, structural diversity, biological activities and pharmacokinetics of iridoids isolated from various genera of the family Scrophulariaceae Juss.

AA Thabet, IM Ayoub, FS Youssef, E Al-Sayed… - Phytomedicine Plus, 2022 - Elsevier
Background Iridoids are naturally occurring oxygenated monoterpenes with wide range of
pharmacological activities. Scrophulariaceae Juss. is a family of flowering plants with 74 …

[HTML][HTML] Orthogonal protection of saccharide polyols through solvent-free one-pot sequences based on regioselective silylations

S Traboni, E Bedini, A Iadonisi - Beilstein Journal of Organic …, 2016 - beilstein-journals.org
Abstract tert-Butyldimethylsilyl (TBDMS) and tert-butyldiphenylsilyl (TBDPS) are alcohol
protecting groups widely employed in organic synthesis in view of their compatibility with a …

Plant-derived verbascoside and isoverbascoside regulate Toll-like receptor 2 and 4-driven neutrophils priming and activation

P Dimitrova, K Alipieva, K Stojanov, V Milanova… - Phytomedicine, 2019 - Elsevier
Background Neutrophils have a short live in circulation and accelerate greatly local immune
responses via increased granulopoiesis and migration at high numbers to infected or …

Study on the chemical reactivity difference of primary hydroxyl groups in iridoid glycosides

Y Kong, J Xu, P Zhu, S Wang, B Yang, J Zhang… - RSC …, 2023 - pubs.rsc.org
Iridoid glycoside, which belongs to the polyhydroxy compound, is a kind of active ingredient
of traditional Chinese medicine with a wide range of sources, and has many …