Drug design strategies that aim to improve the low solubility and poor bioavailability conundrum in quercetin derivatives

SR Alizadeh, N Savadkouhi… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Scientists are especially interested in polyphenols, particularly flavonoids.
Quercetin, a flavonoid, has demonstrated various therapeutic properties, such as …

A Review on the Antimicrobial Activity of Chitosan Microspheres: Milestones Achieved and Miles to Go

M Muthu, SSC Pushparaj, J Gopal… - Journal of Marine Science …, 2023 - mdpi.com
Chitosan is a natural biodegradable polymer that is recovered from marine shell wastes. It
has been widely employed in anticancer, antioxidant, and antibacterial applications due to …

Exploring the osteogenic potential of chitosan-quercetin bio-conjugate: In vitro and in vivo investigations in osteoporosis models

Y Li, V Selvaraj, S Saravanan, SS Abullais… - International Journal of …, 2024 - Elsevier
Anti-osteoporotic agents are clinically employed to improve bone health and prevent
osteoporotic fractures. In the current study, we investigated the potential of chitosan …

Physical, mechanical, and biological performance of chitosan-based nanocomposite coating deposited on the polycaprolactone-based 3D printed scaffold: potential …

FM Najafabadi, S Karbasi, SZ Benisi… - International Journal of …, 2023 - Elsevier
Recently, coating on composite scaffolds has attracted many researchers' attention to
improve scaffolds' properties. In this research, a 3D printed scaffold was fabricated from …

Combinatory Effect of Gemcitabine and 5‐Fluorouracil Investigated Through Chemoinformatics and Molecular Dynamics Simulation Against Breast Cancer

S Sukumaran, A Zochedh, K Chandran… - … Journal of Quantum …, 2024 - Wiley Online Library
Co‐delivering FDA‐approved drugs can be less harmful and boost biological activity by
targeting different protein mechanism at same time. Gemcitabine and 5‐Fluorouracil (GE5F) …

[HTML][HTML] Phytochemistry, antioxidant and anti-diabetic activities of Sterculia villosa in-vitro

D Hajra, A Chouni, S Paul - Pharmacological Research-Modern Chinese …, 2024 - Elsevier
Objective As ongoing research continues, many anti-diabetic agents still have a multitude of
side effects which is the reason why more and more people resort to traditional medicines …

Phytochemical profile, physicochemical, antioxidant and antimicrobial properties of Juniperus phoenicea and Tetraclinis articulate: in vitro and in silico approaches

A Asbabou, T Hanane, AA Gourich, F Siddique… - Frontiers in …, 2024 - frontiersin.org
Introduction This research aims to explore the molecular composition, antioxidant
capabilities, and antibacterial effects of the essential oils from Tetraclinis articulateata and …

[HTML][HTML] Treatment of Inflammatory Bowel Disease by Using Curcumin-Containing Self-Microemulsifying Delivery System: Macroscopic and Microscopic Analysis

N Ameer, M Hanif, G Abbas, M Azeem… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: The lack of local availability for drugs in the colon can be addressed by
preparing a self-microemulsifying drug delivery system (SMEDDS) of curcumin (Cur) which …

Comprehensive chemical profiling with UHPLC-MS, in-vitro, in-silico, and in-vivo antidiabetic potential of Typha domingensis Pers; A novel source of bioactive …

R Dilshad, R Dilshad, S Ahmad, H Rao… - South African Journal of …, 2024 - Elsevier
Aim of study Typha is one of the valuable plant genera in folklore use in diabetes, and it can
be a good source of bioactive chemicals. The current project was planned to investigate the …

Unveiling geniposide from Paederia foetida as a potential antihypertensive treatment: an integrated approach involving in vivo and computational methods

C Koley, A Mondal, S Dey, R Rawat, A Mondal… - Future Journal of …, 2024 - Springer
Background Hypertension is one of the burning topics in today's world. Natural product can
open a new window in the treatment as they are lesser side effect compared to synthetic …