Photoreceptor dysfunctions and degenerative diseases are significant causes of vision loss
in patients, with few effective treatments available. Targeted interventions to prevent or …

We summarize recent findings in different animal models regarding the different cell‐
signaling pathways and gene networks that influence the reprogramming of Müller glia into …

The first steps of vision take place in the ciliary outer segment compartment of photoreceptor
cells. The protein composition of outer segments is uniquely suited to perform this function …

Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders
such as Bardet-Biedl syndrome (BBS). Retinal degeneration is common in ciliopathies …

Unlike mammals, zebrafish regenerate in response to retinal damage. Because microglia
are activated by retinal damage, we investigated their role during regeneration following …

Photoreceptor degeneration leads to irreversible vision loss in humans with retinal
dystrophies such as retinitis pigmentosa. Whereas photoreceptor loss is permanent in …

Zebrafish are an instrumental system for the generation of photoreceptor degeneration
models, which can be utilized to determine underlying causes of photoreceptor dysfunction …

Microglia are resident immune cells in the central nervous system, including the retina that
surveil the environment for damage and infection. Following retinal damage, microglia …

Despite the obvious morphological differences in the visual system, zebrafish share a similar
architecture and components of the same embryonic origin as humans. The zebrafish retina …

The vertebrate retina develops from a specified group of precursor cells that adopt distinct
identities and generate lineages of either the neural retina, retinal pigmented epithelium, or …