Advances to tackle backbone flexibility in protein docking
A Harmalkar, JJ Gray - Current opinion in structural biology, 2021 - Elsevier
Computational docking methods can provide structural models of protein–protein
complexes, but protein backbone flexibility upon association often thwarts accurate …
complexes, but protein backbone flexibility upon association often thwarts accurate …
[HTML][HTML] Nothing regular about the regulins: Distinct functional properties of SERCA transmembrane peptide regulatory subunits
N Rathod, JJ Bak, JO Primeau, MLE Fisher… - International Journal of …, 2021 - mdpi.com
The sarco-endoplasmic reticulum calcium ATPase (SERCA) is responsible for maintaining
calcium homeostasis in all eukaryotic cells by actively transporting calcium from the cytosol …
calcium homeostasis in all eukaryotic cells by actively transporting calcium from the cytosol …
Interaction of DWORF with SERCA and PLB as determined by EPR spectroscopy
MD Rustad, O Roopnarine, RL Cornea… - … and biophysical research …, 2023 - Elsevier
Insufficient sarco/endoplasmic reticulum calcium ATPase (SERCA) activity significantly
contributes to heart failure, which is a leading cause of death worldwide. A characteristic …
contributes to heart failure, which is a leading cause of death worldwide. A characteristic …
FXYD proteins and sodium pump regulatory mechanisms
JQ Yap, J Seflova, R Sweazey, P Artigas… - Journal of General …, 2021 - rupress.org
The sodium/potassium-ATPase (NKA) is the enzyme that establishes gradients of sodium
and potassium across the plasma membrane. NKA activity is tightly regulated for different …
and potassium across the plasma membrane. NKA activity is tightly regulated for different …
Inhibitory and stimulatory micropeptides preferentially bind to different conformations of the cardiac calcium pump
The ATP-dependent ion pump sarco/endoplasmic reticulum Ca 2+-ATPase (SERCA)
sequesters Ca 2+ in the endoplasmic reticulum to establish a reservoir for cell signaling …
sequesters Ca 2+ in the endoplasmic reticulum to establish a reservoir for cell signaling …
[HTML][HTML] Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of calcium
The sarco (endo) plasmic reticulum Ca 2+ ATPase (SERCA) is a membrane transporter that
creates and maintains intracellular Ca 2+ stores. In the heart, SERCA is regulated by an …
creates and maintains intracellular Ca 2+ stores. In the heart, SERCA is regulated by an …
Induced fit with replica exchange improves protein complex structure prediction
Despite the progress in prediction of protein complexes over the last decade, recent blind
protein complex structure prediction challenges revealed limited success rates (less than …
protein complex structure prediction challenges revealed limited success rates (less than …
S100A1ct: A Synthetic Peptide Derived From S100A1 Protein Improves Cardiac Performance and Survival in Preclinical Heart Failure Models
D Kehr, J Ritterhoff, M Glaser, L Jarosch, RE Salazar… - Circulation, 2024 - ahajournals.org
BACKGROUND: The EF-hand Ca2+ sensor protein S100A1 has been identified as a
molecular regulator and enhancer of cardiac performance. The ability of S100A1 to …
molecular regulator and enhancer of cardiac performance. The ability of S100A1 to …
S100A1ct: a synthetic peptide derived from human S100A1 protein improves cardiac contractile performance and survival in pre-clinical heart failure models
D Kehr, J Ritterhoff, M Glaser, L Jarosch, RE Salazar… - bioRxiv, 2023 - biorxiv.org
Abstract Background The EF-hand Ca2+ sensor protein S100A1 has been identified as a
molecular regulator and enhancer of cardiac performance. S100A1's ability to recognize and …
molecular regulator and enhancer of cardiac performance. S100A1's ability to recognize and …
Micropeptide hetero-oligomerization adds complexity to the calcium pump regulatory network
TA Phillips, GT Hauck, MP Pribadi, EE Cho… - Biophysical …, 2023 - cell.com
The sarco (endo) plasmic reticulum calcium ATPase (SERCA) is an ion transporter that
creates and maintains intracellular calcium stores. SERCA is inhibited or stimulated by …
creates and maintains intracellular calcium stores. SERCA is inhibited or stimulated by …