Drug resistance is estimated to affect about a third of individuals with epilepsy, but its
prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other …

Objective Summarize the current evidence on efficacy and tolerability of vagus nerve
stimulation (VNS), responsive neurostimulation (RNS), and deep brain stimulation (DBS) …

Epilepsy is one of most common chronic neurological disorders, and the antiseizure
medications developed by targeting neurocentric mechanisms have not effectively reduced …

Capsaicin is a natural compound found in chili peppers and is used in the diet of many
countries. The important mechanism of action of capsaicin is its influence on TRPV1 …

Drug resistance is a major challenge in the treatment of epilepsy. Drug-resistant epilepsy
(DRE) accounts for 30% of all cases of epilepsy and is a matter of great concern because of …

Despite progress in the development of anti‐seizure medications (ASMs), one third of
people with epilepsy have drug‐resistant epilepsy (DRE). The working definition of DRE …

Objectives Different neurostimulation modalities are available to treat drug-resistant focal
epilepsy when surgery is not an option including vagus nerve stimulation (VNS), responsive …

Background Responsive neurostimulation (RNS) is a novel technology for drug-resistant
epilepsy rising from bilateral hemispheres or eloquent cortex. Although recently approved …

Epilepsy is a common chronic neurological disorder in modern society. One of the major
unmet challenges is that current antiseizure medications are basically not disease …

Neurons maintain their average firing rate and other properties within narrow bounds
despite changing conditions. This homeostatic regulation is achieved using negative …