Spirooxindole: a versatile biologically active heterocyclic scaffold
Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural
spirooxindole-containing compounds have been identified as bio-promising agents …
spirooxindole-containing compounds have been identified as bio-promising agents …
[HTML][HTML] Computer-aided drug design in anti-cancer drug discovery: What have we learnt and what is the way forward?
The escalating prevalence of cancer on a global scale, coupled with the inadequacies of
present-day therapies and the emergence of drug-resistant cancer strains, has necessitated …
present-day therapies and the emergence of drug-resistant cancer strains, has necessitated …
p53 as a potential target for treatment of cancer: A perspective on recent advancements in small molecules with structural insights and SAR studies
Cancer represents one of the world's biggest hazardous diseases. p53 is the uttermost
researched tumour suppressor protein. It is commonly considered the “guardian of the …
researched tumour suppressor protein. It is commonly considered the “guardian of the …
[HTML][HTML] Methyltransferase set7/9 as a multifaceted regulator of ROS response
A Daks, O Shuvalov, O Fedorova… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) induce multiple signaling cascades in the cell and hence
play an important role in the regulation of the cell's fate. ROS can cause irreversible damage …
play an important role in the regulation of the cell's fate. ROS can cause irreversible damage …
Structure-based discovery of novel α-aminoketone derivatives as dual p53-MDM2/MDMX inhibitors for the treatment of cancer
H Luo, D Si, X Sun, M Wang, Y Yang, B Wang… - European Journal of …, 2023 - Elsevier
The function of the p53 protein is impaired by the overexpression of its negative regulator
murine double minute 2 protein (MDM2) and homologous protein MDMX. Disruption of the …
murine double minute 2 protein (MDM2) and homologous protein MDMX. Disruption of the …
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein–Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
J Cheng, Z Yan, K Jiang, C Liu, D Xu… - Journal of Medicinal …, 2023 - ACS Publications
MDM2 and MDM4 cooperatively and negatively regulate p53, while this pathway is often
hijacked by cancer cells in favor of their survival. Blocking MDM2/p53 interaction with small …
hijacked by cancer cells in favor of their survival. Blocking MDM2/p53 interaction with small …
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal …
F Merlino, A Pecoraro, G Longobardi… - Journal of Medicinal …, 2024 - ACS Publications
Colorectal cancer (CRC) often involves wild-type p53 inactivation by MDM2 and MDM4
overexpression, promoting tumor progression and resistance to 5-fluoruracil (5-FU) …
overexpression, promoting tumor progression and resistance to 5-fluoruracil (5-FU) …
Emerging role and therapeutic implications of p53 in intervertebral disc degeneration
Y Wang, S Hu, W Zhang, B Zhang, Z Yang - Cell Death Discovery, 2023 - nature.com
Lower back pain (LBP) is a common degenerative musculoskeletal disease that imposes a
huge economic burden on both individuals and society. With the aggravation of social aging …
huge economic burden on both individuals and society. With the aggravation of social aging …
Advancements in targeting tumor suppressor genes (p53 and BRCA 1/2) in breast cancer therapy
Globally, among numerous cancer subtypes, breast cancer (BC) is one of the most prevalent
forms of cancer affecting the female population. A female's family history significantly …
forms of cancer affecting the female population. A female's family history significantly …
Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties
DR Aboshouk, MA Youssef, MS Bekheit, AR Hamed… - RSC …, 2024 - pubs.rsc.org
Cancer is one of the most significant health challenges worldwide. Various techniques, tools
and therapeutics/materials have been developed in the last few decades for the treatment of …
and therapeutics/materials have been developed in the last few decades for the treatment of …