Cerebrovascular reactivity (CVR) is the cerebral hemodynamic response to a vasoactive
substance. Breath-hold (BH) induced CVR has the advantage of being non-invasive and …

In recent years, technical and procedural advances have brought functional magnetic
resonance imaging (fMRI) to the field of murine neuroscience. Due to its unique capacity to …

The glymphatic system is a brainwide CSF transport system that uses the perivascular space
for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and …

Background and Purpose Recent clinical trials report that metformin, an activator of AMP‐
activated protein kinase (AMPK) used to treat type 2 diabetes, significantly reduces the risk …

Hypertensive small vessel disease is a major cause of vascular cognitive impairment (VCI).
Spontaneously hypertensive/stroke prone rats (SHR/SP) with unilateral carotid artery …

This review provides an in‐depth update on the impact of heat stress on cerebrovascular
functioning. The regulation of cerebral temperature, blood flow, and metabolism are …

Performing a BOLD functional MRI (fMRI) acquisition during breath-hold (BH) tasks is a non-
invasive, robust method to estimate cerebrovascular reactivity (CVR). However, movement …

Arterial hypertension is the main risk factor for stroke and plays a role in the development of
vascular cognitive impairment (VCI) and vascular dementia (VaD). An association between …

Degeneration of cerebral white matter is commonly observed in aging, and the associated
degradation in neural connectivity contributes to cognitive decline in older adults. Vascular …

Most studies involving BOLD fMRI in basic neuroscience research are conducted with
anesthetized animals. This study investigates neural and hemodynamic activity through a …