Human OX40L–CAR-Tregs target activated antigen-presenting cells and control T cell alloreactivity
Regulatory T cells (Tregs) make major contributions to immune homeostasis. Because Treg
dysfunction can lead to both allo-and autoimmunity, there is interest in correcting these …
dysfunction can lead to both allo-and autoimmunity, there is interest in correcting these …
Immune regulation and therapeutic application of T regulatory cells in liver diseases
A Ajith, M Merimi, MK Arki… - Frontiers in …, 2024 - frontiersin.org
CD4+ CD25+ FOXP3+ T regulatory cells (Tregs) are a subset of the immunomodulatory cell
population that can inhibit both innate and adaptive immunity by various regulatory …
population that can inhibit both innate and adaptive immunity by various regulatory …
PTEN is required for human Treg suppression of costimulation in vitro
Regulatory T‐cell (Treg) therapy is under clinical investigation for the treatment of transplant
rejection, autoimmune disease, and graft‐versus‐host disease. With the advent of genome …
rejection, autoimmune disease, and graft‐versus‐host disease. With the advent of genome …
Fourth generation CAR Tregs with PDCD1-driven IL-10 have enhanced suppressive function
DA Boardman, S Mangat, JK Gillies, VCW Fung… - bioRxiv, 2024 - biorxiv.org
The potency of regulatory T cell (Treg) therapy has been transformed through use of
chimeric antigen receptors (CAR). However, to date, CAR Treg therapy has not achieved …
chimeric antigen receptors (CAR). However, to date, CAR Treg therapy has not achieved …
Optimizing a potency assay for regulatory T cell therapies
M Leung - 2023 - open.library.ubc.ca
Regulatory T cells (Tregs) are a promising cell therapy for the prevention of immune-
mediated pathologies including autoimmune diseases, allergy, transplant rejection and graft …
mediated pathologies including autoimmune diseases, allergy, transplant rejection and graft …
PTEN is required for human Treg suppression of costimulation
Regulatory T cell (Treg) therapy is under clinical investigation for the treatment of transplant
rejection, autoimmune disease, and graft-versus-host disease. With the advent of genome …
rejection, autoimmune disease, and graft-versus-host disease. With the advent of genome …
Immunomodulatory Impacts of Immune Checkpoint Proteins and Mutein Cytokines at Homeostasis and Infection
JA Perry - 2022 - search.proquest.com
Regulatory T cells (T reg s) are a specialized subset of CD4+ T cells defined by expression
of the transcription factor Foxp3. These cells have key roles in preventing the development …
of the transcription factor Foxp3. These cells have key roles in preventing the development …