The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has led to an unprecedented effort toward the development of an effective …

Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by a novel
coronavirus, SARS-CoV-2, has infected more than 22 million individuals and resulted in …

Lentiviruses induce a wide variety of pathologies in different animal species. A common
feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a …

The aggressive and recurrent nature of glioblastoma is multifactorial and has been attributed
to its biological heterogeneity, dysfunctional metabolic signaling pathways, rigid blood–brain …

Lentiviral vectors derived from the human immunodeficiency type 1 virus (HIV-1 LV) are
among the finest tools available today for the genetic modification of human monocyte …

Hemophilia A (HA) is a bleeding disorder caused by deficiency of the coagulation factor VIII
(F8). F8 replacement is standard of care, whereas gene therapy (F8 gene) for HA is an …

Selective gene silencing by small interfering RNAs (siRNAs) has been shown to be an
efficient method for the targeted manipulation of cellular functions. Chemical transfection …

Lentiviral vectors (LV) can induce type I interferon (IFN I) production from murine
plasmacytoid dendritic cells (pDC), but not myeloid (my) DC. Here, we investigated whether …

Over the years, the unique capacity of dendritic cells (DC) for efficient activation of naive T
cells has led to their extensive use in cancer immunotherapy protocols. In order to be able to …

Viral modification of dendritic cells (DCs) may deliver a “danger signal” critical to the hypo-
reactive DCs in cancer patients. Using three highly differentially expressed hepatoma tumor …