Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …

There has been an explosion in the number of papers discussing the hypothesis
of'pathogenic spread'in neurodegenerative disease—the idea that abnormal forms of …

Clinical use of allografts of fetal ventral mesencephalic tissue as a treatment to replace
dopaminergic neurons in patients with Parkinson's disease was first done more than 20 …

Parkinson's disease (PD) is recognized by the accumulation of α-synuclein within neurons.
In contrast to the current ascending theory where α-synuclein would propagate from neuron …

The notion that prion-like spreading of misfolded α-synuclein (α-SYN) causes Parkinson9s
disease (PD) has received a great deal of attention. Although attractive in its simplicity, the …

The demonstration that dopamine loss is the key pathological feature of Parkinson's disease
(PD), and the subsequent introduction of levodopa have revolutionalized the field of PD …

Parkinson's Disease (PD) is an intractable disease resulting in localized neurodegeneration
of dopaminergic neurons of the substantia nigra pars compacta. Many current therapies of …

Stem cell-based therapies hold considerable promise for many currently devastating
neurological disorders. Substantial progress has been made in the derivation of disease …

To determine the long-term health and function of transplanted dopamine neurons in
Parkinson's disease (PD) patients, the expression of dopamine transporters (DATs) and …

Multiple laboratories have recently demonstrated that long-term dopaminergic transplants
form Lewy bodies in patients with Parkinson's disease. Debate has arisen as to whether …