In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Peptide–drug conjugates (PDCs) are the next generation of targeted therapeutics drug after
antibody–drug conjugates (ADCs), with the core benefits of enhanced cellular permeability …

The development of therapeutics for effective treatments of retinal diseases is significantly
constrained by various biological barriers. We herein report a nanomedicine strategy to …

Abstract Development of topical bioactive formulations capable of overcoming the low
bioavailability of conventional eye drops is critically important for efficient management of …

Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being
extensively studied due to their excellent delivery performance. Compared with other …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it
clear that combating coronavirus outbreaks benefits from a combination of vaccines and …

Cellular membranes, including the plasma and endosome membranes, are barriers to
outside proteins. Various vehicles have been devised to deliver proteins across the plasma …

Objectives Peptide‐based therapeutics are natural candidates to desirable wound healing.
However, enzymatic surroundings largely limit its stability and bioavailability. Here, we …

Designing artificial viral vectors (AVVs) programmed with biomolecules that can enter
human cells and carry out molecular repairs will have broad applications. Here, we describe …

Simple Summary Crossing biological barriers is often required for drug delivery. Cell-
penetrating peptides (CPPs) are short strands of amino acids that have been widely used as …