Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

An age‐related decline in immune functions, referred to as immunosenescence, is partially
responsible for the increased prevalence and severity of infectious diseases, and the low …

It is recognised that ageing induces various changes to the human colonic microbiota. Most
relevant is a reduction in bifidobacteria, which is a health-positive genus. Prebiotics, such as …

Ageing is accompanied by 2–4-fold increases in plasma/serum levels of inflammatory
mediators such as cytokines and acute phase proteins. A wide range of factors seems to …

Studies have demonstrated that circulating levels of plasma cytokines are influenced greatly
by age and that chronic elevated levels of certain cytokines are associated with chronic …

Aging is associated with increased inflammatory activity reflected by increased circulating
levels of TNF-α, IL-6, cytokine antagonists and acute phase proteins in vivo. Epidemiologic …

The immune system of an organism is an essential component of the defense mechanism
aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed …

Innate and adaptive immune functions decline with age, leading to increased susceptibility
to infectious diseases and cancer, and reduced responses to preventive vaccination in the …

Recent observations indicate that immunosenescence is not accompanied by an
unavoidable and progressive deterioration of the immune function, but is rather the result of …

We assessed association between prior cytomegalovirus (CMV) infection, proinflammatory
status and effectiveness of the anti-influenza vaccination. We examined 154 individuals …