Gastric cancer: advances in carcinogenesis research and new therapeutic strategies

L Seeneevassen, E Bessède, F Mégraud… - International journal of …, 2021 - mdpi.com
Gastric cancer's bad incidence, prognosis, cellular and molecular heterogeneity amongst
others make this disease a major health issue worldwide. Understanding this affliction is a …

Impaired intestinal barrier and tissue bacteria: pathomechanisms for metabolic diseases

L Massier, M Blüher, P Kovacs… - Frontiers in …, 2021 - frontiersin.org
An intact intestinal barrier, representing the interface between inner and outer environments,
is an integral regulator of health. Among several factors, bacteria and their products have …

Intestinal microbiota as a contributor to chronic inflammation and its potential modifications

M Potrykus, S Czaja-Stolc, M Stankiewicz, Ł Kaska… - Nutrients, 2021 - mdpi.com
The gut microbiota is a crucial factor in maintaining homeostasis. The presence of
commensal microorganisms leads to the stimulation of the immune system and its …

Helicobacter pylori VacA, a distinct toxin exerts diverse functionalities in numerous cells: An overview

N Chauhan, ACY Tay, BJ Marshall, U Jain - Helicobacter, 2019 - Wiley Online Library
Background Helicobacter pylori, gastric cancer‐causing bacteria, survive in their gastric
environment of more than 50% of the world population. The presence of H. pylori in the …

Helicobacter pylori: A Contemporary Perspective on Pathogenesis, Diagnosis and Treatment Strategies

A Ali, KI AlHussaini - Microorganisms, 2024 - mdpi.com
Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the gastric
mucosa and is associated with various gastrointestinal disorders. H. pylori is a pervasive …

[HTML][HTML] Targeted therapies in metastatic gastric cancer: Current knowledge and future perspectives

A Pellino, E Riello, F Nappo, S Brignola… - World journal of …, 2019 - ncbi.nlm.nih.gov
Gastric cancer (GC) represents a leading cause of cancer related morbidity and mortality
worldwide accounting for more than 1 million of newly diagnosed cases and thousands of …

Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

C Chen, A Beloqui, Y Xu - Advanced drug delivery reviews, 2023 - Elsevier
Oral administration is the preferred route of administration based on the convenience for and
compliance of the patient. Oral nanomedicines have been developed to overcome the …

Emerging paradigms in inflammatory disease management: Exploring bioactive compounds and the gut microbiota

T Benameur, C Porro, ME Twfieg, N Benameur… - Brain Sciences, 2023 - mdpi.com
The human gut microbiota is a complex ecosystem of mutualistic microorganisms that play a
critical role in maintaining human health through their individual interactions and with the …

Loss of tight junction protein claudin 18 promotes progressive neoplasia development in mouse stomach

SJ Hagen, LH Ang, Y Zheng, SN Karahan, J Wu… - Gastroenterology, 2018 - Elsevier
Background & Aims Loss of claudin 18 (CLDN18), a membrane-spanning tight junction
protein, occurs during early stages of development of gastric cancer and associates with …

The effect of Helicobacter pylori infection and different H. pylori components on the proliferation and apoptosis of gastric epithelial cells and fibroblasts

W Gonciarz, A Krupa, K Hinc, M Obuchowski… - PLoS …, 2019 - journals.plos.org
Background Helicobacter pylori colonizes the human gastric mucosa, causing chronic
inflammation, peptic ulcers and gastric cancer. A cascade of harmful processes results from …