ER exit in physiology and disease
CM Robinson, A Duggan, A Forrester - Frontiers in Molecular …, 2024 - frontiersin.org
The biosynthetic secretory pathway is comprised of multiple steps, modifications and
interactions that form a highly precise pathway of protein trafficking and secretion, that is …
interactions that form a highly precise pathway of protein trafficking and secretion, that is …
Genetic disruption of mammalian endoplasmic reticulum‐associated protein degradation: Human phenotypes and animal and cellular disease models
Endoplasmic reticulum‐associated protein degradation (ERAD) is a stringent quality control
mechanism through which misfolded, unassembled and some native proteins are targeted …
mechanism through which misfolded, unassembled and some native proteins are targeted …
COPII cage assembly factor Sec13 integrates information flow regulating endomembrane function in response to human variation
How information flow is coordinated for managing transit of 1/3 of the genome through
endomembrane pathways by the co at com p lex II (COPII) system in response to human …
endomembrane pathways by the co at com p lex II (COPII) system in response to human …
Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1
J Hirano, T Hayashi, K Kitamura, Y Nishimura… - Journal of …, 2024 - Am Soc Microbiol
Enteroviruses are single-stranded, positive-sense RNA viruses causing endoplasmic
reticulum (ER) stress to induce or modulate downstream signaling pathways known as the …
reticulum (ER) stress to induce or modulate downstream signaling pathways known as the …
A novel chemical chaperone ameliorates osteoblast homeostasis and extracellular matrix in osteogenesis imperfecta
N Garibaldi, R Besio, V Pirota, B Albini, G Colombo… - Life Sciences, 2025 - Elsevier
Aims Osteogenesis imperfecta (OI) is a collagen I-related heritable family of skeletal
diseases associated to extreme bone fragility and deformity. Its classical forms are caused …
diseases associated to extreme bone fragility and deformity. Its classical forms are caused …
PSP205, a Novel Phenyl Sulfonyl Piperidine, Induces Apoptotic Cell Death in Colon Cancer by Modulating Coat Protein Complex-Mediated Vesicle Trafficking
The endoplasmic reticulum (ER) stress and autophagic pathways offer attractive targets for
the development of new cancer drugs. Here, we identified a novel phenyl sulfonyl …
the development of new cancer drugs. Here, we identified a novel phenyl sulfonyl …
COPI Vesicle Disruption Inhibits Mineralization via mTORC1-Mediated Autophagy
J Nie, S Ma, Y Zhang, S Yu, J Yang, A Li… - International Journal of …, 2023 - mdpi.com
Bone mineralization is a sophisticated regulated process composed of crystalline calcium
phosphate and collagen fibril. Autophagy, an evolutionarily conserved degradation system …
phosphate and collagen fibril. Autophagy, an evolutionarily conserved degradation system …
Routing of Kv7. 1 to endoplasmic reticulum plasma membrane junctions
C Serrano‐Novillo, I Estadella… - Acta …, 2024 - Wiley Online Library
Abstract Aim The voltage‐gated Kv7. 1 channel, in association with the regulatory subunit
KCNE1, contributes to the I Ks current in the heart. However, both proteins travel to the …
KCNE1, contributes to the I Ks current in the heart. However, both proteins travel to the …
Oligosaccharyltransferase is involved in targeting to ER-associated degradation
M Shenkman, N Ogen-Shtern, C Patel, B Groisman… - bioRxiv, 2024 - biorxiv.org
The majority of membrane and secretory proteins undergo N-glycosylation, a process
catalyzed by oligosaccharyltransferase (OST), a membrane-bound protein complex that …
catalyzed by oligosaccharyltransferase (OST), a membrane-bound protein complex that …