Current technologies have changed biology into a data-intensive field and significantly
increased our understanding of signal transduction pathways in plants. However, global …

Recent analyses of sequence and microarray data have suggested that alternative splicing
plays a major role in the generation of proteomic and functional diversity in metazoan …

Alternative splicing is one of the most important mechanisms to generate a large number of
mRNA and protein isoforms from the surprisingly low number of human genes. Unlike …

Numerous disease-associated point mutations exert their effects by disrupting the activity of
exonic splicing enhancers (ESEs). We previously derived position weight matrices to predict …

The study of cellular signalling over the past 20 years and the advent of high-throughput
technologies are enabling the reconstruction of large-scale signalling networks. After careful …

Recent advances in large-scale genome sequencing projects have opened up new
possibilities for the application of conventional mutation techniques in not only forward but …

Exponential growth of the peer-reviewed literature and the breakdown of disciplinary
boundaries heralded by genome-scale instruments have made it harder than ever for …

The precise regulation of many alternative splicing (AS) events by specific splicing factors is
essential to determine tissue types and developmental stages. However, the molecular …

Drosophila Dscam encodes 38,016 distinct axon guidance receptors through the mutually
exclusive alternative splicing of 95 variable exons. Importantly, known mechanisms that …

The exon/intron architecture of genes determines whether components of the spliceosome
recognize splice sites across the intron or across the exon. Using in vitro splicing assays, we …